Sunday, December 23, 2012

High Fructose Corn Syrup - Metabolism of Fructose

Metabolism of Fructose:

Sucrose, a disaccharide, is composed of equal amounts of fructose and glucose. High fructose corn syrup, as the name implies, is higher in fructose than glucose. Fructose and glucose are both monosaccharides.

Now the question is the ability of the human body cells to metabolize fructose in comparison to glucose. The name High fructose corn syrup that gives the impression that it contains a large amount of fructose. The content of fructose is only 55% versus 50% in sucrose. Sucrose is pure disaccharide of only glucose and fructose. The reason HFCS has more than 50% fructose is because the glucose extracted from corn starch is enzymatically treated ( Man is entering the picture) to convert some of the glucose to fructose. This treatment of the corn starch is done to make the sugar sweeter which is why it is so popular in the food industry. The enzymatically treatment is not done by the body but is artificially administered to increase the level of fructose. Any disorder and/or dysfunction attributed to the consumption of fructose can manifest whether one consumes cane sugar or beet sugar or HFCS. Plain old sucrose is the enemy.

Glucose metabolism is subject to a negative feedback system. When the hypothalamus metabolizes glucose a signaling pathway is initiated that results in the suppression of food intake and the ultimate release of glucose in the process of digestion. This feedback system prevents you from eating too much food. Changes in neuropeptide expression results in suppressed food intake while simultaneously increasing overall energy expenditure for the many very active cells that comprise muscle and neural tissue, for example. This is normal since an energy supply is necessary for active cells.

This is in contrast to fructose metabolism. The brain and the liver possess a unique set of transporters and enzymes that enable fructose to bypass a very important reaction that controls the rate limiting step in glycolysis that is critical in the regulation of ATP production and consumption. Glycogen is a stored sugar chemical in the liver that, when broken down, releases glucose into the bloodstream from the liver. If there is nothing ready to use the excess glucose it is converted to fat. You don't want that!

When the hypothalamus fructose metabolism bypasses the above regulatory step its metabolism rapidly depletes ATP in the hypothalamus. This leads to a series of chemical reactions that make the effects of glucose metabolism and fructose metabolism very different even though they utilize the same signaling pathway to control food intake. Keep this in mind. It is important to understand why fructose can lead to diabetes and obesity.

Fructose is highly correlated with the development of diabetes, obesity and a metabolic syndrome. Fructose metabolism differs from glucose metabolism in that fructose  causes the formation of uric acid. A chemical is acted upon by uric acid that causes a very rapid depletion of ATP, the main source of chemical energy for body cells. When the body senses the loss of stored ATP it signals for food intake to manufacture the ATP it senses it, the body , needs. This chemical is not subject to feedback inhibition such as is the case  for glucose metabolism. This results in a very large ATP depletion. This cycle repeats itself and more food is taken in and the breakdown product are stored as fat. You, in other words, get fatter and fatter. Since the liver is the source for the majority of fructose metabolism the depletion of ATP, in the liver, has a direct effect on other liver metabolic procedures. An increase in uric acid formation takes place after a series of chemical changes in the liver.

This increase in the level of serum uric acid is directly associated with the prediction for the development of obesity and hypertension. Gout is another disorder that is associated with the excess production of uric acid. Increased consumption of HFCS can lead to an increase in the symptoms of gout. 

The metabolic syndrome results in laboratory test animals resulted in increases in obesity, visceral fat accumulation, fatty liver and elevated insulin levels. Changes in other chemicals after fructose consumption may account for increased food intake that could result in weight gain. 

Keep in mind the consumption of any of the basic sources of sugar from sugar cane, sugar beets and corn starch all contain fructose. Abuse of sugar, any sugar, intake has serious effects on your health.



  1. In case pancreas system is unable to produce insulin in the body then this medicine is highly recommended to control the sugar level.
    Insulin | Buy Insulin | Insulin UK

  2. Hygetropin is well suited for building muscles, loss body fat, increase energy, endurance, improve the immune system, normalize the blood pressure
    Hygetropin | Hygetropin UK | Buy Hygetropin UK

  3. The medicine effectively stimulates the linear tissue growth and enables the children and teenagers to grow naturally. It improves metabolism to decrease the fat deposition in the body.
    Jintropin| Jintropin UK | Buy Jintropin UK

  4. Kigtropin is prepared to provide the several advantages such as decrease wrinkles and cellulite, increase muscle mass, loss body fat and weight loss.
    Kigtropin | Kigtropin UK | Buy Kigtropin UK

  5. Riptropin is made for those who are suffering from lack of natural growth hormone in their body, either adults or kids. Riptropin increases muscle development.
    Riptropin| Riptropin UK | Buy Riptropin UK

  6. Somatropin contains active sequence of 191 amino acid, sole chain of polypeptide. It works on increasing the body growth specifically in kids and adolescences.
    Somatropin |Somatropin UK | Buy Somatropin UK

  7. Buy Zopiclone Sleeping Tablets & Pills securely and discreetly without a prescription at Sleeping Pills Direct. Our prices on Zopiclone Sleeping Pills are cheap.
    Zopiclone | Buy Zopiclone Online | Zopiclone 7.5 mg

  8. Ambien is orally ingested and comes in the form of a pill. As its fast acting, it is recommended you swallow a pill before having a meal and jumping into bed.
    Ambien | Ambien UK | Buy Ambien UK

  9. Valium affects the chemicals in your brain that can become unbalanced and cause anxiety. Valium is used to treat muscle spasms, alcohol withdrawal symptoms and anxiety disorders.
    Valium | Buy Valium Online | Buy Valium Online UK

  10. Xanax is an alprazolam medication recommended for the treatment of anxiety disorders and panic disorders. It belongs to the benzodiazepines group of medications.
    Xanax | Xanax UK | Buy Xanax UK

  11. Zolpidem sleeping pills are taken once before bedtime. Never take more than the recommended dosage as this can be dangerous, especially when takenwith other drugs.
    zolpidem | buy zolpidem | buy zolpidem uk

  12. is the supplier of erectile dysfunction medicine online that you can purchase securely and safely through our system. We supply kamagra that we receive directly from authenticated, reputed and trustworthy manufactures.
    Kamagra | Buy Kamagra UK | Cheap Kamagra UK

  13. Kamagra discounts strives to keep and enhance every aspect of our business and meet the ends needs of our customers well. Products at our site are 100% ready for delivery.
    Kamagra | Buy Kamagra uk | Cheap Kamagra UK

  14. We provide the lowest price sildamax medicine that you can hardly find any other place. Moreover refund policy is also applied if the customers are not satisfied with our products.
    Sildamax | Buy Sildamax Uk |Cheap Sildamax UK

  15. Sildamax usually become effective within an hour after consumption and can last between two and six hours. Sildamax is manufactured in state of the art factories under clinically clean conditions.
    Sildamax | Buy 100 Sildamax Tablets - Sildamax Now

  16. has established itself as one of the leading suppliers of Melanotan peptides by offering the excellent quality peptides at the nominal cost.
    Melanotan 2 | Melanotan 2 uk | Buy Melanotan 2 UK

  17. currently the leading providers of Melanotan 2 in the world. We offer affordable prices on high quality products, keeping the purity as high as it can possibly be.
    Melanotan 2 | Melanotan 2 uk | Buy Melanotan 2 uk

  18. Sleeping pills store is the UK’s leading health website providing valuable information and quality insomnia products to help people overcome sleep disorders, anxiety and depression.
    Sleeping Pills Store | Buy Sleeping Pills | Sleeping Pills Uk

  19. Growth hormone uk has emerged with an objective to serve for wellness of people with high quality medical products made by the international leading brands.
    Growth Hormone UK | Growth Hormone | hgh for sale

  20. Symptoms of diabetes can be similar in type 1 diabetes, typically diagnosed in children and teens, and type 2 diabetes, which most often occurs in adults. Early symptoms of any type of diabetes are related to high blood and urine glucose levels and include dehydration, hunger, increased urination, and increased thirst. Other symptoms can include weight loss or gain, fatigue, nausea, vomiting, blurred vision, and increased susceptibility to infections. Vaginal infections in women and yeast infections in both men and women are common. Other symptoms can include dry mouth, itching skin, and slow-healing wounds, cuts, or sores.

  21. Thanks for this information. Thanks for sharing, those who are having problem related to metabolic activity may try the Acai Berry Juice, or noni juice that have enough power to solve your problem as researches shows that they are full of anti-oxidants and antibiotics.

  22. As a sign of gratitude for how my husband was saved from diabetes , i decided to reach out to those still suffering from this.
    My husband was diagnosed of diabetes and it was really tough and heartbreaking for me because he was my all and the symptoms were terrible, he had difficulty eating, and he always complain of stomach pain and he always have frequent urination . we tried various therapies prescribed by our neurologist but none could cure him. I searched for a cure and i saw a testimony by someone who was cured and so many other with similar body problem, and he left the contact of the doctor who had the cure to diabetes . I never imagine diabetes has a cure not until i contacted him and he assured me my husband will be fine. I got the herbal medication he recommended and my husband used it and in one months he was fully okay even up till this moment he is so full of life. diabetes has a cure and it is a herbal cure contact the doctor for more info on on how to get the medication. Thanks for reading my testimony